American Lies in the Middle East

The United States is playing fast and loose with the facts regarding the Japanese ship in the Strait of Hormus on June 14. While the United States claims the ship was attacked with limpet mines, the ship captain disputes this account. The captain of the ship Courageous stated that the ship was not attacked with mines and photographs show the damage and fire were well above the water line. The ship captain believed the ship might have been hit by a flying object. In any case the U.S. claim of Iranian mine attack is patently false.

While the U.S. is looking for any excuse to go to war against Iran, this instance will not serve. The U.S. claims are rightly being denied by our allies except for Great Britain who slavishly supports any American military adventure. If the U.S. wants renewed respect in the world it must stop obvious lies. Iran has given us no reason to go to war but America has engaged in economic attacks and enforced boycotts of Iran. Enough of the lies. The time when American could make up excuses for war is long past.

Mueller Report

Many liberals and even leftists put unwarranted faith in the Mueller investigation which apart from indictments of all the President’s men disappointed on every issue regarding the President and Russian collusion. While I never had faith in Mueller given his history, temperament and and Washington establishment leanings, the reality of hiss whitewash of the President in the face of Trump’s self evident quilt is disturbing.

Apparently see no evil still prevails in Washington despite the fact that the emperor has no clothes. Most of America can see that even if Mueller is blind.

Censorship continues apace

USA Today reports that Facebook will extend its censorship to anti-vaccine news. USA Today states:

‘Facebook is considering making anti-vaccination content on its site less visible amid a measles outbreak that has reignited a conversation about preventative shots.

The social media giant that’s been criticized for spreading fake news told USA TODAY it’s “taken steps to reduce the distribution of health-related misinformation on Facebook, but we know we have more to do.”

Facebook has been fighting misinformation on its platform since the 2016 presidential election after fake accounts and news stories aimed at sowing discord among users were discovered.’

Facebook, YouTube, Amazon and others announce censorship plans

Not only are social media censoring left political ideas but, now, extending this censorship to medical issues regarding vaccines and other unpopular ideas. The victims of this censorship is the left, natural medicine, and those pointing to deficiencies in current vaccines. It should be noted that we now have the technology and knowledge to make safer and more effective vaccines. Among those censoring are Facebook, YouTube, Amazon and other social media.

Those voices who normally raise concerns about censorship and demand free speech are strangely and cowardly absent today.

Small molecule nicotinamideN-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

[**Biochemical Pharmacology**][Biochemical Pharmacology]

Available online 10 February 201

**Abstract**

Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that proliferate, differentiate to fusion-competent myoblasts, and facilitate muscle regeneration are increasingly dysfunctional upon aging, impairing muscle recovery after injury. While regulators of muSC activity can offer novel therapeutics to improve recovery and reduce morbidity among aged adults, there are no known muSC regenerative small molecule therapeutics. We recently developed small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed with aging in skeletal muscles and linked to impairment of the NAD\\+ salvage pathway, dysregulated sirtuin 1 activity, and increased muSC senescence. We hypothesized that NNMT inhibitor (NNMTi) treatment will rescue age-related deficits in muSC activity to promote superior regeneration post-injury in aging muscle. 24-month old mice were treated with saline (control), and low and high dose NNMTi (5 and 10 mg/kg) for 1-week post-injury, or control and high dose NNMTi for 3-weeks post-injury. All mice underwent an acute muscle injury (barium chloride injection) locally to the tibialis anterior (TA) muscle, and received 5-ethynyl-2’-deoxyuridine systemically to analyze muSC activity. *In vivo*contractile function measurements were conducted on the injured TA muscle and tissues collected for ex-vivo analyses, including myofiber cross-sectional area (CSA) measurements to assess muscle recovery. Results revealed that muscle stem cell proliferation and subsequent fusion were elevated in NNMTi-treated mice, supporting nearly 2-fold greater CSA and shifts in fiber size distribution to greater proportions of larger sized myofibers and fewer smaller sized fibers in NNMTi-treated mice compared to controls. Prolonged NNMTi treatment post-injury further augmented myofiber regeneration evinced by increasingly larger fiber CSA. Importantly, improved muSC activity translated not only to larger myofibers after injury but also to greater contractile function, with the peak torque of the TA increased by ∼70% in NNMTi-treated mice compared to controls. Similar results were recapitulated *in vitro* with C2C12 myoblasts, where NNMTi treatment promoted and enhanced myoblast differentiation with supporting changes in the cellular NAD\\+/NADH redox states. Taken together, these results provide the first clear evidence that NNMT inhibitors constitute a viable pharmacological approach to enhance aged muscle regeneration by rescuing muSC function, supporting the development of NNMTi as novel mechanism-of-action therapeutic to improve skeletal muscle regenerative capacity and functional recovery after musculoskeletal injury in older adults

[Biochemical Pharmacology]: https://www.sciencedirect.com/science/journal/00062952
[In Press_ Accepted]: https://www.sciencedirect.com/science/journal/aip/00062952
[What]: https://service.elsevier.com/app/answers/detail/a_id/22799/supporthub/sciencedirect/
[HarshiniNeelakantan]: https://www.sciencedirect.com/science/article/abs/pii/S0006295219300462?via%3Dihub#!
[https]: https://doi.org/10.1016/j.bcp.2019.02.008
[Get]: https://s100.copyright.com/AppDispatchServlet?publisherName=ELS&contentID=S0006295219300462&orderBeanReset=true

Planned Iran misadventure behind need to overthrow Venezuelan government.

The real reason behind the USA plot to overthrow the Venezuela government is the need for a stable oil supply during the wrong headed Trump administration planned assault on Iran

The long term goal of the Trump administration faction led by John Bolton is Iran but the overriding problem with John Bolton’s plan is the fact that such action would block shipping in the Persian gulf. The straits of Hormous rest on Iranian soil and, if blocked, stop 35 percent of the world’s oil traffic from the gulf including Saudi Arabia and all gulf nations.

The problem facing John Bolton and the Trump administration is in finding a reliable replacement for the loss of Arabian oil during an future war against Iran. The solution would appear to be Venezuela. However, U.S. relations with Venezuela are not amicable. Further, Venezuela just signed long term contracts to supply its oil to China. Hence American need to overthrow the Venezuela government in order to further Bolton’s plan to attack Iran.

And why attack Iran? Israel views Iran as a potential threat despite US intelligence reports that Iran has complied with US requirements to cease manufacturing refined uranium suitable for bombs. But reality has never clouded the Trump administration views.

USA led coup attempt in Venezuela on January 23 has so far failed .

The United States tried to engineer a coup in Venezuela Wed., January 23, 2019. Trump was expecting the Venezuela Army to desert the government and support the opposition leader picked by the USA. The United States signaled its desire by recognizing the opposition minority leader as the legitimate ruler and getting several client states to follow suit. Venezuela responded by breaking diplomatic relations with the United States and ordering its diplomats to leave in 72 hours. The United States refused to withdraw the diplomats by saying it does not recognize the authority of the Venezuela government. Trump, who has a history of advocating military intervention in Venezuela, may now use the claim that the safety of United States diplomats are endangered in Venezuela as an excuse for military intervention to overthrow the government in Venezuela.

Such intervention would surely trigger opposition in the rest of Latin America and the world at large. We are very close to a return to gunboat diplomacy with all the evils that entails to self determination and democracy for the people of Latin America.

Trump sets stage for military conflict in Venezuela

The Trump administration has withdrawn recognition of the elected Venezuela government prompting Venezuela to issue an order expelling American diplomats giving 72 hours to leave. Trump refuses to withdraw diplomats thereby setting stage for a military overthrow of the government in Venezuela under the guise of protecting diplomats illegally in Venezuela.

Sabre rattlingly by the USA will inevitably lead to military conflict.