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Mueller Report

Many liberals and even leftists put unwarranted faith in the Mueller investigation which apart from indictments of all the President’s men disappointed on every issue regarding the President and Russian collusion. While I never had faith in Mueller given his history, temperament and and Washington establishment leanings, the reality of hiss whitewash of the President in the face of Trump’s self evident quilt is disturbing.

Apparently see no evil still prevails in Washington despite the fact that the emperor has no clothes. Most of America can see that even if Mueller is blind.

Censorship continues apace

USA Today reports that Facebook will extend its censorship to anti-vaccine news. USA Today states:

‘Facebook is considering making anti-vaccination content on its site less visible amid a measles outbreak that has reignited a conversation about preventative shots.

The social media giant that’s been criticized for spreading fake news told USA TODAY it’s “taken steps to reduce the distribution of health-related misinformation on Facebook, but we know we have more to do.”

Facebook has been fighting misinformation on its platform since the 2016 presidential election after fake accounts and news stories aimed at sowing discord among users were discovered.’

Facebook, YouTube, Amazon and others announce censorship plans

Not only are social media censoring left political ideas but, now, extending this censorship to medical issues regarding vaccines and other unpopular ideas. The victims of this censorship is the left, natural medicine, and those pointing to deficiencies in current vaccines. It should be noted that we now have the technology and knowledge to make safer and more effective vaccines. Among those censoring are Facebook, YouTube, Amazon and other social media.

Those voices who normally raise concerns about censorship and demand free speech are strangely and cowardly absent today.

Small molecule nicotinamideN-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

[**Biochemical Pharmacology**][Biochemical Pharmacology]

Available online 10 February 201

**Abstract**

Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that proliferate, differentiate to fusion-competent myoblasts, and facilitate muscle regeneration are increasingly dysfunctional upon aging, impairing muscle recovery after injury. While regulators of muSC activity can offer novel therapeutics to improve recovery and reduce morbidity among aged adults, there are no known muSC regenerative small molecule therapeutics. We recently developed small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed with aging in skeletal muscles and linked to impairment of the NAD\\+ salvage pathway, dysregulated sirtuin 1 activity, and increased muSC senescence. We hypothesized that NNMT inhibitor (NNMTi) treatment will rescue age-related deficits in muSC activity to promote superior regeneration post-injury in aging muscle. 24-month old mice were treated with saline (control), and low and high dose NNMTi (5 and 10 mg/kg) for 1-week post-injury, or control and high dose NNMTi for 3-weeks post-injury. All mice underwent an acute muscle injury (barium chloride injection) locally to the tibialis anterior (TA) muscle, and received 5-ethynyl-2’-deoxyuridine systemically to analyze muSC activity. *In vivo*contractile function measurements were conducted on the injured TA muscle and tissues collected for ex-vivo analyses, including myofiber cross-sectional area (CSA) measurements to assess muscle recovery. Results revealed that muscle stem cell proliferation and subsequent fusion were elevated in NNMTi-treated mice, supporting nearly 2-fold greater CSA and shifts in fiber size distribution to greater proportions of larger sized myofibers and fewer smaller sized fibers in NNMTi-treated mice compared to controls. Prolonged NNMTi treatment post-injury further augmented myofiber regeneration evinced by increasingly larger fiber CSA. Importantly, improved muSC activity translated not only to larger myofibers after injury but also to greater contractile function, with the peak torque of the TA increased by ∼70% in NNMTi-treated mice compared to controls. Similar results were recapitulated *in vitro* with C2C12 myoblasts, where NNMTi treatment promoted and enhanced myoblast differentiation with supporting changes in the cellular NAD\\+/NADH redox states. Taken together, these results provide the first clear evidence that NNMT inhibitors constitute a viable pharmacological approach to enhance aged muscle regeneration by rescuing muSC function, supporting the development of NNMTi as novel mechanism-of-action therapeutic to improve skeletal muscle regenerative capacity and functional recovery after musculoskeletal injury in older adults

[Biochemical Pharmacology]: https://www.sciencedirect.com/science/journal/00062952
[In Press_ Accepted]: https://www.sciencedirect.com/science/journal/aip/00062952
[What]: https://service.elsevier.com/app/answers/detail/a_id/22799/supporthub/sciencedirect/
[HarshiniNeelakantan]: https://www.sciencedirect.com/science/article/abs/pii/S0006295219300462?via%3Dihub#!
[https]: https://doi.org/10.1016/j.bcp.2019.02.008
[Get]: https://s100.copyright.com/AppDispatchServlet?publisherName=ELS&contentID=S0006295219300462&orderBeanReset=true

Planned Iran misadventure behind need to overthrow Venezuelan government.

The real reason behind the USA plot to overthrow the Venezuela government is the need for a stable oil supply during the wrong headed Trump administration planned assault on Iran

The long term goal of the Trump administration faction led by John Bolton is Iran but the overriding problem with John Bolton’s plan is the fact that such action would block shipping in the Persian gulf. The straits of Hormous rest on Iranian soil and, if blocked, stop 35 percent of the world’s oil traffic from the gulf including Saudi Arabia and all gulf nations.

The problem facing John Bolton and the Trump administration is in finding a reliable replacement for the loss of Arabian oil during an future war against Iran. The solution would appear to be Venezuela. However, U.S. relations with Venezuela are not amicable. Further, Venezuela just signed long term contracts to supply its oil to China. Hence American need to overthrow the Venezuela government in order to further Bolton’s plan to attack Iran.

And why attack Iran? Israel views Iran as a potential threat despite US intelligence reports that Iran has complied with US requirements to cease manufacturing refined uranium suitable for bombs. But reality has never clouded the Trump administration views.

USA led coup attempt in Venezuela on January 23 has so far failed .

The United States tried to engineer a coup in Venezuela Wed., January 23, 2019. Trump was expecting the Venezuela Army to desert the government and support the opposition leader picked by the USA. The United States signaled its desire by recognizing the opposition minority leader as the legitimate ruler and getting several client states to follow suit. Venezuela responded by breaking diplomatic relations with the United States and ordering its diplomats to leave in 72 hours. The United States refused to withdraw the diplomats by saying it does not recognize the authority of the Venezuela government. Trump, who has a history of advocating military intervention in Venezuela, may now use the claim that the safety of United States diplomats are endangered in Venezuela as an excuse for military intervention to overthrow the government in Venezuela.

Such intervention would surely trigger opposition in the rest of Latin America and the world at large. We are very close to a return to gunboat diplomacy with all the evils that entails to self determination and democracy for the people of Latin America.

Trump sets stage for military conflict in Venezuela

The Trump administration has withdrawn recognition of the elected Venezuela government prompting Venezuela to issue an order expelling American diplomats giving 72 hours to leave. Trump refuses to withdraw diplomats thereby setting stage for a military overthrow of the government in Venezuela under the guise of protecting diplomats illegally in Venezuela.

Sabre rattlingly by the USA will inevitably lead to military conflict.

Venezuela’s VP to Mike Pence: ‘Yankee, Go Home’ | News | teleSUR English

Published 22 January 2019 (20 hours 33 minutes ago)

While the so-called Lima Group and the U.S. refused to recognize Maduro’s new mandate, many progressive governments and international organizations have shown support and solidarity to Maduro.

Venezuelan Vice President Delcy Rodriguez Tuesday said U.S. Vice President Mike Pence was “openly calling for a coup d’état in Venezuela ” after Pence issued a video message of support to the Venezuelan opposition to encourage those who are protesting against President Nicolas Maduro and underline U.S. backing for opposition lawmaker Juan Guaido, the self-appointed head of the suspended National Assembly.

RELATED:
Venezuelan President Renews Calls for Regional Integration Amid Diplomatic Attacks

The Venezuelan VP’s statement followed an earlier message from Venezuelan Information Minister Jorge Rodriguez who said Pence was, “promoting instability and violence in Venezuela.”

“Because Mr. Pence doesn’t have a job, now he wants to come and run Venezuela, handing out instructions on what should happen in Venezuela tomorrow,” Rodriguez said in a press in a short statement following Pence’s interventionist message. “Openly calling for a coup d’état in Venezuela. I will say it like the Venezuelan people would say it to you, ‘Yankee, go home.’ We’re not going to allow you to intrude on issues of the country of Bolivar and the country of Hugo Chavez.”

Venezuela’s opposition on Wednesday plans to hold marches nationwide as part of an annual event that marks the fall of a military government in 1958.

In a taped video message in English with a few Spanish words and phrases mixed in, Pence, who has lashed out at Maduro before, declared him a “dictator” who has no rightful claim to power.

Pence declared U.S. support again for Guaido, with whom he spoke by phone earlier this month, and the suspended National Assembly, which he leads, as the “last vestige of democracy.” Pence said Washington supported Guaido’s decision to assert the body’s powers, declare Maduro a “usurper” and push for a transitional government to be established.

The decision by the suspended National Assembly to appoint Guaido as the head of the body was invalidated by the country’s Supreme Court because the body itself has been in contempt of court since 2016.

On Jan. 11, 2016, the Supreme Court of Justice declared the National Assembly in contempt of court for swearing in three deputies from the self-appointed Unity Roundtable (MUD) elected by the state of Amazonas in December 2015. The three Indigenous legislators should have been temporarily suspended because of voting irregularities in that region, but instead took possession of their seats on July 28.

The contempt of court is maintained to this day because the new board of the assembly refuses to accept the judgments of the top court.

Venezuelan President Nicolas Maduro was inaugurated for a second term in office on Jan. 10 and his term would last until 2025. His new term comes amid continuing economic war against the country and its people using harsh economic sanctions led by the United States in an effort to oust Maduro and his progressive government.

While the so-called Lima Group, the United States and other right-wing governments refused to recognize Maduro’s new mandate, many progressive governments and international organizations have shown support and solidarity to Maduro. It is a critical moment for the region and the world amid a rise in right-wing politics and governments such as that of far-right Jair Bolsonaro in Brazil.

Rotavirus vaccine reduces type 1 diabetes in children.

Science Daily
Possible link between rotavirus vaccine and decline in type 1 diabetes
Date:
January 22, 2019
Source:
Walter and Eliza Hall Institute
Summary:
A drop in the number of young children diagnosed with type 1 diabetes could be associated with the introduction of routine rotavirus vaccination of Australian infants.


A drop in the number of young children diagnosed with type 1 diabetes could be associated with the introduction of routine rotavirus vaccination of Australian infants, according to a new study by Melbourne researchers.

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The researchers investigated the number of Australian children diagnosed with type 1 diabetes from 2000 to 2015 and found that type 1 diabetes diagnoses in children aged 0-4 years declined from 2007 — the year that rotavirus vaccine was introduced as a routine infant vaccination.

This is the first time the rate of type 1 diabetes in young children in Australia has fallen since the 1980s. While not conclusively linking the rotavirus vaccine with protection against type 1 diabetes, the discovery builds on earlier research suggesting natural rotavirus infection may be a risk factor for type 1 diabetes.

The study, a collaboration led by the Murdoch Children’s Research Institute and Walter and Eliza Hall Institute clinician scientists, was published in JAMA Pediatrics today.

Decline in type 1 diabetes

Since the 1980s, the incidence of type 1 diabetes has steadily increased in Australia and worldwide, but the reasons for this increase are poorly understood. Type 1 diabetes is a serious, lifelong autoimmune condition, in which the body’s immune system destroys cells in the pancreas that produce insulin, a hormone that controls the level of glucose in the blood.

By investigating the number of Australian children diagnosed with type 1 diabetes each year since 2000, the research team observed that after 2007 the rate of type 1 diabetes decreased in children aged 0-4 years, said study lead Dr Kirsten Perrett from the Murdoch Children’s Research Institute.

“The significant decrease in type 1 diabetes that we detected in young children after 2007 was not seen in older children aged 5-14. This suggests the young children could have been exposed to a protective factor that didn’t impact older children,” Dr Perrett said.

“We observed the decline in the rate of type 1 diabetes in children born after 2007 coincided with the introduction of the oral rotavirus vaccine onto the Australian National Immunisation Program in 2007.”

The rotavirus vaccine is routinely given to Australian infants aged 2 and 4 months to protect them against a severe, potentially life-threatening form of diarrhoea.

Exploring the connection

Professor Len Harrison from the Walter and Eliza Hall Institute, who is the study senior author, said the discovery followed on from earlier research implicating rotavirus infection in the development of type 1 diabetes.

“Twenty years ago our team revealed an association between the appearance of immune markers of type 1 diabetes in children and rotavirus infection. Subsequent studies in laboratory models suggested rotavirus infection of pancreatic cells can trigger an immune attack against the insulin-producing cells — similar to what occurs in type 1 diabetes,” he said.

“While not conclusive, our latest study suggests that preventing rotavirus infection in Australian infants by vaccination may also reduce their risk of type 1 diabetes. We will be continuing this research to look more closely at the correlation, by comparing the health records of young children with or without type 1 diabetes.

“At this stage we don’t yet know whether the reduction in type 1 diabetes is a permanent effect or transient, and it may only be relevant to Australian children,” Professor Harrison said.

The research was supported by the National Health and Medical Research Council (ECF APP1054394), a Melbourne Children’s Clinician-Scientist Fellowship, a Murdoch Children’s Research Institute grant, the Colin North Diabetes Fund and the Victorian Government.

Story Source:

Materials provided by Walter and Eliza Hall Institute. Note: Content may be edited for style and length.

Journal Reference:

Kirsten P. Perrett, Kim Jachno, Terry M. Nolan, Leonard C. Harrison. Association of Rotavirus Vaccination With the Incidence of Type 1 Diabetes in Children. JAMA Pediatrics, 2019; DOI: 10.1001/jamapediatrics.2018.4578
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Walter and Eliza Hall Institute. “Possible link between rotavirus vaccine and decline in type 1 diabetes.” ScienceDaily. ScienceDaily, 22 January 2019. <www.sciencedaily.com/releases/2019/01/22