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FLU Vaccine Effectiveness May Wane 16% Every 28 Days

Influenza virus engulfs most northern states when it’s snowing and continues through early spring
vaccination being given in arm

September 12th, 2018 – A new study suggests that the effectiveness of inactivated influenza vaccine wanes during the course of a single season.

Which refreshes the question ‘when is the optimal timing of seasonal influenza vaccination.’

This study’s results may lead to the Centers for Disease Control and Prevention (CDC)’s reconsideration of obtaining a flu shot before November 1st each year.

The study was published in Clinical Infectious Diseases, and compared persons vaccinated 14 to 41 days prior to being tested for influenza to persons vaccinated 42 to 69 days prior to being tested. The persons vaccinated 42 to 69 days before testing had 1.32 times the odds of testing positive for any influenza.

These researchers from Kaiser Permanente found the odds ratio (OR) increased in a linear fashion by approximately 16% for each additional 28 days since vaccination.

This means the OR was 2.06 for personsvaccinated 154 or more days prior to being teste

Most of the vaccine waning was associated with influenza A protection since that virus strain represented 80 percent of the confirmed cases in this study.

Recently, there have been other studies that have also shown influenza vaccine effectiveness waning.

Generally, the influenza virus engulfs the northern hemisphere when it’s snowing each year.

However, in 75 percent of recent influenza seasons, peak flu activity had not occurred until January or later, regardless of where you live, says the CDC.

Moreover, to make this flu shot timing decision even more confusing, there could be more than 1 influenza outbreak in a single year.

Regardless of these issues, the CDC’s Advisory Committee on Immunization Practices (ACIP) says the flu shot should be administered no later than the end of October.

References:

Multiple sclerosis drug slows brain shrinkage, study finds: Trial offers hope for disease with limited treatment options — ScienceDaily

Results from a clinical trial of more than 250 participants with progressive multiple sclerosis (MS) revealed that ibudilast was better than a placebo in slowing down brain shrinkage. The study also showed that the main side effects of ibudilast were gastrointestinal and headaches. The study was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, and published in the New England Journal of Medicine.

Herpes causes Alzheimers

Neuron June 21, 2018

“Investigators have long suspected that pathogenic microbes might contribute to the onset and progression of Alzheimer’s disease (AD) although definitive evidence has not been presented. Whether such findings represent a causal contribution, or reflect opportunistic passengers of neurodegeneration, is also difficult to resolve…
“We observed increased human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) from subjects with AD compared with controls. These results were replicated in two additional, independent and geographically dispersed cohorts.”

SIMIAN VIRUS 40 CONTAMINATION OF SALK POLIO VACCINE INCREASED CANCER RATES FOR SELECT CANCER TYPES

Anticancer Res. 1999 May-Jun;19(3B):2173-80.
Cancer risk associated with simian virus 40 contaminated polio vaccine.
Fisher SG1, Weber L, Carbone M.
Author information
Abstract
BACKGROUND:
The presence of SV40 in monkey cell cultures used in the preparation of the polio vaccine from 1955 through 1961 is well documented. Investigations have consistently demonstrated the oncogenic behavior of SV40 in animal models. Early epidemiologic studies were inadequate in demonstrating an increase in cancer incidence associated with contaminated vaccine. Recently, investigators have provided persuasive evidence that SV40 is present in human ependymomas, choroid plexus tumors, bone tumors, and mesotheliomas, however, the etiologic role of the virus in tumorigenesis has not been established.

MATERIALS AND METHODS:
Using data from SEER, we analyzed the incidence of brain tumors, bone tumors, and mesotheliomas from 1973-1993 and the possible relationship of these tumors with the administration of the SV40 contaminated vaccine.

RESULTS:
Our analysis indicates increased rates of ependymomas (37%), osteogenic sarcomas (26%), other bone tumors (34%) and mesothelioma (90%) among those in the exposed as compared to the unexposed birth cohort.

CONCLUSIONS:
These data suggest that there may be an increased incidence of certain cancers among the 98 million persons exposed to contaminated polio vaccine in the U.S.; further investigations are clearly justified.

Cellular & Molecular Immunology. 2018 Mar 5; Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction.